Arts&Culture

Many women uninformed about breast cancer surgery options

Many women uninformed about breast cancer surgery options

The BRCA mutation may be most famous for its association with Angelina Jolie, who announced she carried the BRCA1 mutation in 2013 in a New York Times opinion piece. On Friday, Jan. 12, 2018, the Food and Drug Administration approved AstraZeneca PLC's Lynparza, the first drug aimed at women with advanced breast cancer caused by an inherited flawed gene.

The study of 2,733 British women also found a double mastectomy did not improve survival rates for patients with the mutation 10 years later.

U.S. regulators have approved the first drug to treat women with advanced breast cancers caused by the same flawed gene that Angelina Jolie made famous.

The researchers say that in the future this information could help women and their doctors make informed choices about treatment.

Ellen R. Copson, Ph.D., from the University of Southampton in the United Kingdom, and colleagues conducted a prospective cohort study involving female patients recruited from 127 hospitals in the United Kingdom who were aged 40 years or younger at first diagnosis of invasive breast cancer.

The BRCA1 and BRCA2 genes usually produce molecules inside cells that help to fix DNA. AstraZeneca and Merck are working together to deliver Lynparza as quickly as possible to more patients across multiple settings, including breast, ovarian, prostate, and pancreatic cancers. The mutations put women at greater risk of breast and ovarian cancers, with 45 to 90 per cent of women with the mutation developing breast cancer during their lifetime. Eccles added that the results could give women "more confidence and control" when making decisions about their treatment.

Winter Storm Warning Issued As Temps Dip, Snow In Sight
Forecasters at the weather service in Birmingham said winds could be sustained at 20-30 miles per hour with higher gusts. With no snow on Wednesday , Madison's January and 2018 snow total stayed at 0.7 inches, 3.3 inches below normal.

Young women with the BRCA gene mutation that prompted actress Angelina Jolie's pre-emptive and much-publicised double mastectomy are not more likely to die after a breast cancer diagnosis, scientists said Friday.

Some women have previously chose to take preventative measures, such as pre-emptive mastectomies, when they discover they have faulty genes.

Dr. Susan M. Domchek, Executive Director of the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania and a national leader on the OlympiAD trials, said: "Patients diagnosed with BRCA-related metastatic breast cancer are often younger than other breast cancer patients, and their disease is often much more aggressive and hard to treat".

"It can be hard for some patients to decide whether or not to have risk-reducing surgery, typically double mastectomies and removal of ovaries". This surgery did not appear to improve their chances of survival at the 10-year mark, according to the findings published in The Lancet Oncology.

'However, our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment. About 12 percent of women are diagnosed with breast cancer at some point in their life. "Decisions about timing of additional surgery to reduce future cancer risks should take into account patient prognosis after their first cancer, and their personal preferences".


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